USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: O14974 USC-OGP 2-DE database:  O14974 O14974 General information about the entry View entry in simple text format Entry name MYPT1_HUMAN Primary accession number O14974 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Protein phosphatase 1 regulatory subunit 12A; AltName: Full=Myosin phosphatase-targeting subunit 1; Short=Myosin phosphatase target subunit 1; AltName: Full=Protein phosphatase myosin-binding subunit;. Gene name Name=PPP1R12A {ECO:0000312|HGNC:HGNC:7618} Synonyms=MBS, MYPT1 {ECO:0000305} Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0130: pI=4.80; Mw=34447 SPOT OGP-0132: pI=4.81; Mw=33755 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1096: pI=5.26; Mw=148284 Cross-references UniProtKB/Swiss-Prot O14974; MYPT1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name MYPT1_HUMAN Primary accession number O14974 Secondary accession number(s) B4DZ09 F8VWB4 Q2NKL4 Q569H0 Q86WU3 Q8NFR6 Q9BYH0 Sequence was last modified on  January 1, 1998 (version 1) Annotations were last modified on  March 15, 2017 (version 164) Name and origin of the protein Description RecName: Full=Protein phosphatase 1 regulatory subunit 12A; AltName: Full=Myosin phosphatase-targeting subunit 1; Short=Myosin phosphatase target subunit 1; AltName: Full=Protein phosphatase myosin-binding subunit; Gene name Name=PPP1R12A {ECO:0000312|HGNC:HGNC:7618} Synonyms=MBS, MYPT1 {ECO:0000305} Encoded on Name=PPP1R12A {ECO:0000312|HGNC:HGNC:7618}; Synonyms=MBS, MYPT1 {ECO:0000305 Keywords 3D-structure; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Direct protein sequencing; Hydroxylation; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D87930; BAA22378.1; -; mRNA EMBL AY380574; AAQ88438.1; -; mRNA EMBL AF458589; AAM49717.1; -; mRNA EMBL AK302692; BAG63921.1; -; mRNA EMBL AC018476; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC073569; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC074270; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC047898; AAH47898.1; ALT_SEQ; mRNA EMBL BC092481; AAH92481.1; ALT_SEQ; mRNA EMBL BC111752; AAI11753.1; -; mRNA EMBL AB042196; BAB39107.1; -; Genomic_DNA CCDS CCDS44947.1; -. [O14974-1]; . CCDS CCDS44948.1; -. [O14974-5]; . CCDS CCDS58259.1; -. [O14974-3]; . CCDS CCDS58260.1; -. [O14974-2]; . RefSeq NP_001137357.1; NM_001143885.1. [O14974-1]; . RefSeq NP_001137358.1; NM_001143886.1. [O14974-5]; . RefSeq NP_001231919.1; NM_001244990.1. [O14974-2]; . RefSeq NP_001231921.1; NM_001244992.1. [O14974-3]; . RefSeq NP_002471.1; NM_002480.2. [O14974-1]; . RefSeq XP_011536685.1; XM_011538383.2. [O14974-4]; . UniGene Hs.49582; -; . PDB 2KJY; NMR; -; A=658-714 PDB 5HUZ; NMR; -; A/B=931-978 PDBsum 2KJY; -; . PDBsum 5HUZ; -; . ProteinModelPortal O14974; -; . SMR O14974; -; . BioGrid 110742; 92; . DIP DIP-33186N; -; . IntAct O14974; 59; . MINT MINT-195983; -; . STRING 9606.ENSP00000261207; -; . iPTMnet O14974; -; . PhosphoSitePlus O14974; -; . BioMuta PPP1R12A; -; . OGP O14974; -; . EPD O14974; -; . MaxQB O14974; -; . PaxDb O14974; -; . PeptideAtlas O14974; -; . PRIDE O14974; -; . Ensembl ENST00000261207; ENSP00000261207; ENSG00000058272. [O14974-1]; . Ensembl ENST00000437004; ENSP00000416769; ENSG00000058272. [O14974-2]; . Ensembl ENST00000450142; ENSP00000389168; ENSG00000058272. [O14974-1]; . Ensembl ENST00000546369; ENSP00000449514; ENSG00000058272. [O14974-5]; . Ensembl ENST00000550107; ENSP00000446855; ENSG00000058272. [O14974-3]; . GeneID 4659; -; . KEGG hsa:4659; -; . UCSC uc001syz.4; human. [O14974-1]; . CTD 4659; -; . DisGeNET 4659; -; . GeneCards PPP1R12A; -; . H-InvDB HIX0010848; -; . HGNC HGNC:7618; PPP1R12A; . HPA HPA041296; -; . HPA HPA071956; -; . MIM 602021; gene; . neXtProt NX_O14974; -; . OpenTargets ENSG00000058272; -; . PharmGKB PA33617; -; . eggNOG KOG0505; Eukaryota; . eggNOG COG0666; LUCA; . GeneTree ENSGT00760000119141; -; . HOGENOM HOG000290648; -; . HOVERGEN HBG052561; -; . InParanoid O14974; -; . KO K06270; -; . OMA TDKQTTT; -; . OrthoDB EOG091G12CT; -; . PhylomeDB O14974; -; . TreeFam TF105543; -; . BRENDA 3.1.3.53; 2681; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-5625740; RHO GTPases activate PKNs; . Reactome R-HSA-5627117; RHO GTPases Activate ROCKs; . Reactome R-HSA-5627123; RHO GTPases activate PAKs; . SIGNOR O14974; -; . ChiTaRS PPP1R12A; human; . EvolutionaryTrace O14974; -; . GeneWiki PPP1R12A; -; . GenomeRNAi 4659; -; . PRO PR:O14974; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000058272; -; . CleanEx HS_PPP1R12A; -; . ExpressionAtlas O14974; baseline and differential; . Genevisible O14974; HS; . GO GO:0031672; C:A band; ISS:UniProtKB; . GO GO:0015629; C:actin cytoskeleton; IDA:HPA; . GO GO:0005813; C:centrosome; IDA:UniProtKB; . GO GO:0043292; C:contractile fiber; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0000776; C:kinetochore; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0072357; C:PTW/PP1 phosphatase complex; IDA:UniProtKB; . GO GO:0030018; C:Z disc; ISS:UniProtKB; . GO GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB; . GO GO:0004857; F:enzyme inhibitor activity; IDA:UniProtKB; . GO GO:0019208; F:phosphatase regulator activity; IDA:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0004871; F:signal transducer activity; NAS:ProtInc; . GO GO:0035690; P:cellular response to drug; IEA:Ensembl; . GO GO:0051297; P:centrosome organization; IMP:UniProtKB; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0007067; P:mitotic nuclear division; IMP:UniProtKB; . GO GO:0043086; P:negative regulation of catalytic activity; IDA:UniProtKB; . GO GO:0035508; P:positive regulation of myosin-light-chain-phosphatase activity; IMP:UniProtKB; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0006470; P:protein dephosphorylation; IMP:UniProtKB; . GO GO:0030155; P:regulation of cell adhesion; IDA:UniProtKB; . GO GO:0035507; P:regulation of myosin-light-chain-phosphatase activity; IDA:UniProtKB; . GO GO:0046822; P:regulation of nucleocytoplasmic transport; IEA:Ensembl; . Gene3D 1.25.40.20; -; 1; . InterPro IPR002110; Ankyrin_rpt; . InterPro IPR020683; Ankyrin_rpt-contain_dom; . InterPro IPR017401; MYPT1/MYPT2_chordates; . InterPro IPR031775; PRKG1_interact; . Pfam PF12796; Ank_2; 2; . Pfam PF15898; PRKG1_interact; 1; . PIRSF PIRSF038141; PP1_12ABC_vert; 1; . PRINTS PR01415; ANKYRIN; . SMART SM00248; ANK; 6; . SUPFAM SSF48403; SSF48403; 1; . PROSITE PS50297; ANK_REP_REGION; 1; . PROSITE PS50088; ANK_REPEAT; 4; .

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